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technology



small molecule

the vision

Endogena Therapeutics' approach for endogenous regenerative medicine will result in a novel treatment paradigm for common degenerative diseases that are becoming more prevalent due to demographic changes.


small molecule

mission

Endogena Therapeutics is focusing its drug discovery and development efforts on indications with high unmet medical needs.

small molecule

endogenous regeneration meets small-molecule medicine

Recent discoveries in stem cell biology together with technological advances for phenotypic, functional screening, have unlocked our ability to harness the potential of adult stem- and progenitor cells. Our novel drug discovery approach is based on the concept of selective regulation of these endogenous cells for controlled tissue repair by small molecules.

pipeline

in our most advanced programs, we are targeting degenerative diseases of the eye, including retinitis pigmentosa, which progressively leads to complete loss of vision – our pioneering approach enables the discovery of breakthrough therapies based on cutting-edge knowledge of molecular pathways that regulate retinal stem cells and retinal pigment epithelial cells, which nourish the eye’s photoreceptors and retina.



pipeline schematic




retinis pigmentosa eye

Retinitis pigmentosa (RP)

is a group of inherited diseases causing slow and progressive retinal degeneration and loss of vision. Collaborating with leading vitreoretinal specialists and experts in the ophthalmology field, in our most advance program we will initiate first clinical studies of our novel treatment paradigm in 2021 .


Age-related macular degeneration (AMD)

AMD is a leading cause of irreversible vision loss in the developed world and it has been estimated that almost 9% of the population older than 45 years of age are affected. Dry-AMD is associated with atrophic cell death of the central retina or macula and it accounts for 80-90% of the AMD population. Unfortunately, there is no approved treatment for this condition.

AMD eye



news

Oversubscribed Series A-1 funding round completed

Endogena Therapeutics closed today their first round of Series A financing, which was capped at $8 million. This first round of Series A financing was led by existing investors, Rejuveron Life Sciences AG and DEFTA Partners, with new investors joining the syndicate.

Matthias Steger, CEO of Endogena, said: “This Series A-1 funding will enable us to complete first clinical proof-of-concept studies of our novel treatment paradigm for patients with devastating degenerative eye conditions.” Find out more here.





Endogena selected for JLABS/SVB Pitch event

Endogena Therapeutics has been selected as one of six high-potential companies from the global JLABS ecosystem to present at the JLABS/SVB Investor event on September 10th.

Endogena's CEO, Matthias Steger, will give an update on how Endogena’s proprietary drug discovery platform is driving our programs in Retinitis Pigmentosa and dry AMD through the pipeline, bringing us ever-closer to a revolution in the treatment of these life-altering conditions, and at combatting sight loss. Find out more here, or see us pitch (we're on at 13:35).





Moreno Menghini appointed chief medical officer

Endogena is very pleased to announce that Dr. Moreno Menghini was appointed as CMO. Dr. Menghini is a vitreoretinal surgeon with clinical trial experience in retinal degeneration and will lead Endogena's upcoming clinical studies.
"I am very excited to be part of the pioneering team at Endogena, and as such be at the forefront of medical innovation." Dr. Menghini says.





people

partners


At Endogena, we strongly believe in the potential of innovation by collaboration and accordingly, we work with world-leading partners in academia and industry to leverage state-of-the-art discoveries and technologies

careers

open positions:


We are always on the lookout for exceptional talent to join our growing team:
please feel free to send an unsolicited application to careers@endogena.com

contact us

  • endogena therapeutics, inc.
    111 pine street | san francisco
    ca 94111 | usa
  • info@endogena.com
  • wagistrasse 18
    ch-8952 schlieren | switzerland